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GM(1 4

医院中子照射器I型堆 3

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COVID-19 2

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Hot deformation behavior of a novel bimetal consisting of BTW1 and Q345R characterized by processing

Pengtao LIU, Lifeng MA, Weitao JIA, Tao WANG, Guanghui ZHAO

《机械工程前沿（英文）》 2019年第14卷第4期页码 489-495 doi: 10.1007/s11465-019-0554-x

摘要： Only a few studies have been conducted on the flow behavior of the novel BTW1/Q345R bimetal, which is widely used in coal equipment. In this work, compression tests were conducted on BTW1/Q345R bimetal at a temperature range of 950 °C–1200 °C and strain rates of 0.05, 0.5, 5, and 15 s by using a Gleeble-3800 thermomechanical simulator. A constitutive equation was validated by referring to the Arrhenius equation during the characterization of hot workability. The computed apparent activation energy of the BTW1/Q345R bimetal was 360 kJ/mol, and processing maps under different strain conditions were drawn. Analysis of the stress-strain relationship revealed that work hardening exerted a dominant effect on the thermal deformation of the BTW1/Q345R bimetal. The processing maps predicted that the optimal processing interval will increase with strain. Results showed that thermal deformation of the BTW1/Q345R bimetal should proceed when the temperature range varies from 1182 °C to 1200 °C and the strain rate interval is from 4.2 to 15 s .

关键词： BTW1/Q345R bimetal constitutive equation processing map work hardening

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R158Q and G212S, novel pathogenic compound heterozygous variants in of Gitelman syndrome

《医学前沿（英文）》 2022年第16卷第6期页码 932-945 doi: 10.1007/s11684-022-0963-9

摘要： The dysfunction of Na⁺-Cl⁻ cotransporter (NCC) caused by mutations in solute carrier family12, member 3 gene (SLC12A3) primarily causes Gitelman syndrome (GS). In identifying the pathogenicity of R158Q and G212S variants of SLC12A3, we evaluated the pathogenicity by bioinformatic, expression, and localization analysis of two variants from a patient in our cohort. The prediction of mutant protein showed that p.R158Q and p.G212S could alter protein’s three-dimensional structure. Western blot showed a decrease of mutant Ncc. Immunofluorescence of the two mutations revealed a diffuse positive staining below the plasma membrane. Meanwhile, we conducted a compound heterozygous model—Ncc R156Q/G210S mice corresponding to human NCC R158Q/G212S. Ncc^R156Q/G210S mice clearly exhibited typical GS features, including hypokalemia, hypomagnesemia, and increased fractional excretion of K⁺ and Mg²⁺ with a normal blood pressure level, which made Ncc^R156Q/G210S mice an optimal mouse model for further study of GS. A dramatic decrease and abnormal localization of the mutant Ncc in distal convoluted tubules contributed to the phenotype. The hydrochlorothiazide test showed a loss of function of mutant Ncc in Ncc^R156Q/G210S mice. These findings indicated that R158Q and G212S variants of SLC12A3 were pathogenic variants of GS.

关键词： Gitelman syndrome mouse model compound heterozygous hypokalemia Slc12a3

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Alkali-thermal gasification and hydrogen generation potential of biomass

Tong, Ramin R. Farnood, Charles Q. Jia

《化学科学与工程前沿（英文）》 2017年第11卷第3期页码 369-378 doi: 10.1007/s11705-017-1662-y

摘要： Generating hydrogen gas from biomass is one approach to lowering dependencies on fossil fuels for energy and chemical feedstock, as well as reducing greenhouse gas emissions. Using both equilibrium simulations and batch experiments with NaOH as a model alkaline, this study established the technical feasibility of converting various biomasses (e.g., glucose, cellulose, xylan and lignin) into H -rich gas via catalyst-free, alkali-thermal gasification at moderate temperatures (as low as 300 °C). This process could produce more H with less carbon-containing gases in the product than other comparable methods. It was shown that alkali-thermal gasification follows , with carbonate being the solid product which is different from the one suggested in the literature. Moreover, the concept of hydrogen generation potential (H -GP)—the maximum amount of H that a biomass can yield, was introduced. For a given biomass C H O , the H -GP would be moles of H . It was demonstrated experimentally that the H -GP was achievable by adjusting the amounts of H O and NaOH, temperature and pressure.

关键词： hydrogen generation potential biomass lignocellulose alkali-thermal gasification sodium hydroxide

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Modeling of alkali-silica reaction in concrete: a review

WANG, Q.C. SUN, C.H. ZHANG, D.R.J. OWEN

《结构与土木工程前沿（英文）》 2012年第6卷第1期页码 1-18 doi: 10.1007/s11709-012-0141-2

摘要： This paper presents a comprehensive review of modeling of alkali-silica reaction (ASR) in concrete. Such modeling is essential for investigating the chemical expansion mechanism and the subsequent influence on the mechanical aspects of the material. The concept of ASR and the mechanism of expansion are first outlined, and the state-of-the-art of modeling for ASR, the focus of the paper, is then presented in detail. The modeling includes theoretical approaches, meso- and macroscopic models for ASR analysis. The theoretical approaches dealt with the chemical reaction mechanism and were used for predicting pessimum size of aggregate. Mesoscopic models have attempted to explain the mechanism of mechanical deterioration of ASR-affected concrete at material scale. The macroscopic models, chemo-mechanical coupling models, have been generally developed by combining the chemical reaction kinetics with linear or nonlinear mechanical constitutive, and were applied to reproduce and predict the long-term behavior of structures suffering from ASR. Finally, a conclusion and discussion of the modeling are given.

关键词： alkali-silica reaction (ASR) modeling concrete mesoscopic macroscopic

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二硫化铼超薄纳米片的制备及其在调Q掺铒光纤激光器中的应用 Research

何俊杉1,2,3,4,曾国华1,刘绍贤1,卢海明1,谢锐贤1,戚晶晶1, 陶丽丽1,周博2,3,4

《信息与电子工程前沿（英文）》 2021年第22卷第3期页码 287-436 doi: 10.1631/FITEE.2000339

摘要：本文通过液相剥离法从自制二硫化铼粉末中制备二硫化铼超薄纳米片，并将其应用在调Q掺铒光纤激光器中。将二硫化铼/PVA复合薄膜作为可饱和吸收体放入掺铒光纤激光器中可以获得调Q脉冲输出，脉冲宽度最窄为2.4 μs，输出功率为1.25 mW，揭示了二硫化铼在Q调制方面的潜在应用价值。

关键词：二硫化铼；可饱和吸收体；二维材料；调Q光纤激光器

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基于拓扑绝缘体Sb2Te3的52 nm宽谱可调谐被动调Q掺镱光纤激光器 Research

王涛1,俞强1,2,郭琨1,史鑫尧2,阚雪芬3,徐轶君4,5,吴坚1,4,张凯2,周朴1

《信息与电子工程前沿（英文）》 2021年第22卷第3期页码 287-436 doi: 10.1631/FITEE.2000577

摘要：在本研究中，首先将拓扑绝缘体家族中的二维材料Sb2Te3可饱和吸收体应用在宽谱可调谐被动调Q掺镱光纤激光器中。基于此可饱和吸收体，在掺镱光纤环形腔中获得稳定的波长可调谐被动调Q脉冲，其中心波长可从1040.89 nm连续调节到1092.85 nm。

关键词：拓扑绝缘体；Sb2Te3；光纤激光；被动调Q激光；波长可调谐激光

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线性离散时间系统H∞控制的极小极大Q-学习设计 Research Articles

李新兴1,奚乐乐2,3,查文中1,彭志红2

《信息与电子工程前沿（英文）》 2022年第23卷第3期页码 438-451 doi: 10.1631/FITEE.2000446

摘要：为求解涉及的博弈代数黎卡提方程，在离线策略算法基础上提出一种新型无模型极小极大Q-学习算法，并证明离线策略迭代算法是求解博弈代数黎卡提方程的牛顿法。提出的极小极大Q-学习算法采用离轨策略强化学习技术，利用行为策略产生的系统状态数据，可实现对最优控制器和最佳干扰策略的在线学习。不同于当前Q-学习算法，本文提出一种基于梯度的策略提高方法。证明在一定持续激励条件下，对于初始可行的控制策略并结合合适学习率，提出的极小极大Q-学习算法可收敛到鞍点策略。将提出的极小极大Q-学习算法用于受负载扰动的电力系统H∞负载频率控制器设计，仿真结果表明，最终得到的H∞负载频率控制器具有良好抗干扰性能。

关键词： H∞控制；零和动态博弈；强化学习；自适应动态规划；极小极大Q-学习；策略迭代

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适于低成本嵌入式硬件的2R-1C模型非迭代参数估计 Article

Mitar SIMIĆ, Zdenka BABIĆ, Vladimir RISOJEVIĆ, Goran M. STOJANOVIĆ

《信息与电子工程前沿（英文）》 2020年第21卷第3期页码 476-490 doi: 10.1631/FITEE.1900112

摘要： 2R-1C模型的参数估计常运用需要高性能处理单元的迭代方法，从而激励我们研究更省时且更节能的参数估计方法。这些低复杂度的算法将更适于便携式微机设备的运行。运用一组封闭表达式从测量阻抗的实部和虚部计算2R-1C模型的参数。对仿真和测量获得的模型阻抗数据作对比分析；结果表明，相较于我们早前提出的非迭代参数估计方法（NIPE），QINIPE能减少80%测量点，且所有估计参数的相对估计误差低于1%。此外，比较了QINIPE和复杂非线性最小二乘法（CNLS）对2R-1C模型参数的估计。结果表明，虽然QINIPE估计精度稍低于CNLS，其依然适合许多实际应用，且运行时间降至原来的1/45至1/30。

关键词： 2R-1C模型；嵌入式系统；参数估计；非迭代方法；二次型

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Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

《医学前沿（英文）》 2009年第3卷第1期页码 36-40 doi: 10.1007/s11684-009-0020-y

摘要： This study aims to investigate the influence of β-elemene on the secretion of angiotensin II (ANG II) and the expression of angiotensin receptor type 1 (AT1R) in hepatic stellate cells (HSCs). , HSC-T6 were cultured for 24 hours and then treated with different doses of β-elemene (2.5, 5 and 10 mg/L). A control group was also set up. The secretion of ANG II in the supernatant was detected by radioimmunoassay. The mRNA expression of AT1R at 4, 12 and 24 h after treatment was detected by reverse transcription-polymerase chain reaction (RT-PCR), respectively. The protein expression of AT1R was detected by western blot. At the 4th h, the ANG II secretion in the supernatant was significantly inhibited by 10 mg/L β-elemene compared with the control group ( <0.05), while 5.0 mg/L and 2.5 mg/L β-elemene had no inhibitory effect on the secretion of ANG II ( >0.05). At the time point of the 12th h, the secretion of ANG II in the supernatant treated with 10 mg/L and 5.0 mg/L β-elemene was significantly lower than the control ( <0.01, <0.05). Following the treatment with 5.0 mg/L and 2.5 mg/L β-elemene for 24 h, significant inhibition of ANG II secretion was observed ( <0.05), but 10 mg/L β-elemene had no such effect. β-elemene significantly reduced the amount of AT1R mRNA in HSCs after the treatment for 4, 12, and 24 h in a dose-dependent manner. The expression of AT1R protein also decreased after the treatment with β-elemene for 24 h. β-elemene can inhibit the secretion of ANG II and the gene and protein expression of AT1R, which may be the mechanism by which β-elemene prevents the progress of hepatic fibrosis.

关键词： liver cirrhosis beta-elemene hepatic stellate cells angiotensin II receptor angiotensin type 1

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特定领域问答网站中的标签自然顺序研究

贾俊芳1,李国强2

《信息与电子工程前沿（英文）》 2021年第22卷第2期页码 141-286 doi: 10.1631/FITEE.1900645

摘要：标注是Web 2.0的一个重要特征。它使得社会计算系统（如问答网站）的用户们可以自由地标记内容。然而，标注真的是自由不受限的吗？现有工作表明，用户们常常可以隐性地就哪种标签最能描述在线社区的内容达成共识。然而，目前还没有针对用户在标注过程中对标签排序的规律性开展研究。本文专注于研究特定领域问答网站中的标签自然排序，并对CodeProject，SegmentFault，Biostars以及CareerCup 4个问答网站上数以百万计的问题中的标签序列进行研究。结果表明，这些问答网站的用户可以就问题标签的排序达成隐性共识。研究了标签之间的关系，这些关系可以解释标签自然顺序的出现。该研究为利用标签的自然顺序提升现有标签推荐以及问答站点导航提供了可能。

关键词：问答网站；标注；自然顺序；Skip gram

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PAK1 is a novel cardiac protective signaling molecule

null

《医学前沿（英文）》 2014年第8卷第4期页码 399-403 doi: 10.1007/s11684-014-0380-9

摘要：

We review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinase 1 (PAK1), a member of a serine/threonine protein kinase family. Despite the large body of evidence from studies in noncardiac tissue indicating that PAK1 activity is key in the regulation of a number of cellular functions, the role of PAK1 in the heart has only been revealed over the past few years. In this review, we assemble an overview of the recent findings on PAK1 signaling in the heart, particularly its cardiac protective effects. We present a model for PAK1 signaling that provides a mechanism for specifically affecting cardiac cellular processes in which regulation of protein phosphorylation states by protein phosphatase 2A (PP2A) predominates. We discuss the anti-adrenergic and antihypertrophic cardiac protective effects of PAK1, as well as its role in maintaining ventricular Ca²⁺ homeostasis and electrophysiological stability under physiological, β-adrenergic and hypertrophic stress conditions.

关键词： p21-activated kinase 1 (PAK1) heart

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Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

《结构与土木工程前沿（英文）》 2014年第8卷第4期页码 448-455 doi: 10.1007/s11709-014-0262-x

摘要： Rock mass classification system is very suitable for various engineering design and stability analysis. classification method is confirmed by Japan Highway Public Corporation that this method can figure out either strength or deformability of rock mass, further appropriating the amount of rock bolts, thickness of shotcrete, and size of pitch of steel ribs just after the blasting procedure. Based on these advantages of method, in this study, according to data of five deep and long tunnels in Iran, two equations for estimating the value of method from and classification systems were developed. These equations as a new method were able to optimize the support system for and classification systems. From classification and its application in these case studies, it is pointed out that the method for the design of support systems in underground working is more reliable than the and classification systems.

关键词： JH classification Q and RMR classification new method

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An approach for evaluating fire resistance of high strength Q460 steel columns

Wei-Yong WANG, Guo-Qiang LI, Bao-lin YU

《结构与土木工程前沿（英文）》 2014年第8卷第1期页码 26-35 doi: 10.1007/s11709-014-0239-9

摘要： To develop a methodology for evaluating fire resistance of high strength Q460 steel columns, the load bearing capacity of high strength Q460 steel columns is investigated. The current approach of evaluating load bearing capacity of mild steel columns at room temperature is extended to high strength Q460 steel columns with due consideration to high temperature properties of high strength Q460 steel. The critical temperature of high strength Q460 steel column is presented and compared with mild steel columns. The proposed approach was validated by comparing the predicted load capacity with that evaluated through finite element analysis and test results. In addition, parametric studies were carried out by employing the proposed approach to study the effect of residual stress and geometrical imperfections. Results from parametric studies show that, only for a long column (slenderness higher than 75), the magnitude and distribution mode of residual stress have little influence on ultimate load bearing capacity of high strength Q460 steel columns, but the geometrical imperfections have significant influence on any columns. At a certain slenderness ratio, the stability factor first decreases and then increases with temperature rise.

关键词： high strength Q460 steel load bearing capacity temperature

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智简无线网络理论与技术 Editorial

张平1,彭木根1,崔曙光2,张朝阳3,毛国强4,全智5,Tony Q. S. QUEK6,荣波7

《信息与电子工程前沿（英文）》 2022年第23卷第1期页码 1-4 doi: 10.1631/FITEE.2210000

摘要： With the acceleration of a new round of global scientific, technological, and industrial revolution, the next generation of information and communication technology, i.e., 6G, will inject new momentum into industry transformation and upgrad-ing, as well as into economic innovation and development. This will subsequently promote a global industrial integration. Wireless communication will be ubiquitous in all areas of future society, supporting novel applications with various performance requirements, such as immersive- or interactive-experience applications requiring a large bandwidth, autonomous driving and vehicle-to-everything applications requiring ultra-high reliability and ultra-low latency, and applications for industrial Internet requiring massive machine-type connectivity. Facing the challenges of the post-Moore and post-pandemic era, wireless communication needs breakthroughs in network architecture to improve the intelligence, security, robustness, bandwidth, and heterogeneity. With this background, several important tendencies have emerged in the development of 6G wireless communications: 1. Future wireless networks will evolve from “human-to-human” communications into intelligent “human-to-machine” communications. In addition to enabling communications among humans, future wireless networks will be able to support close connections among humans and machines. The behavior and intent of humans will be sensed and communicated to machines that will accordingly adjust their operations. Typical scenarios include smart building, intelligent transportation, mixed reality (MR), and others. 2. Network nodes will evolve from carrying out only traditional communications to carrying out communication, sensing, computation, management, and caching in an integrated manner. To meet the diverse service requirements of mobile MR, intelligent transportation, industrial Internet of Things, and other areas, future networks will possess multiple functionalities. For example, by sensing human head position, pre-caching necessary content, and rendering high-quality images, network nodes can provide fully immersive MR experiences. In addition, with artificial intelligence (AI), network nodes can manage multi-dimensional resources in an on-demand fashion, where intent-driven network management and control can be realized. 3. Network architecture will focus on collaborations between the cloud and the network edge, which will become more heterogenous. To shorten latency and alleviate the backhaul/fronthaul burden, the network edge must collaborate with the cloud. The first method of collaboration is that the cloud finishes AI model training and then deploys AI models into the network edge, which supports the so-called edge intelligence. In the second method, users demanding high throughput are served via a cloud radio access mode, while users requiring ultra-low latency can benefit from edge computation and caching. As for architecture heterogeneity, future networks are envisioned to incorporate unmanned aerial vehicle (UAV) networks, satellite communica-tion networks, and dense cellular networks, bringing three-dimensional and hierarchical network coverage. In short, the evolution of existing 5G technolo-gies and the development of 6G need to address more stringent and diverse application scenarios, a more strict energy constraint, and the orchestration of multi-dimensional resources. These challenges call for an intellicise wireless network operation paradigm, where “intellicise” is a new adjective that we coin, standing for intelligence-endogenous and primitive-concise. Built upon the integration of AI and next-generation networking technologies, an intellicise wireless network continually explores and exploits new intelligent primitives, e.g., semantic base (Seb) in semantic communications, proactively takes sys-tematic entropy reduction as the global optimization objective, adaptively reshapes the core models of information systems, and ultimately endows itself with endogenous intelligence and primitive conciseness. In this context, the journal has organized a special feature on the theory and techniques for intellicise wireless networks. This special feature covers information theory, architecture design, and intellicise wireless networks for achieving air-space-ground-sea integration, resource management, hardware testbeds and platforms, as well as related applications. In addition, this feature is intended to provide a review of advancements and future research directions in the research field of intellicise wireless networks. After a rigorous review process, six papers have been selected for this feature, including one review article and five research articles.

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MDLB：一种基于强化学习的元数据动态负载均衡机制 Research Articles

武兆琪1,卫今2,3,张帆1,郭威1,谢光伟2,3

《信息与电子工程前沿（英文）》 2020年第21卷第7期页码 963-1118 doi: 10.1631/FITEE.1900121

摘要：采用Q_learning算法，所提基于强化学习机制由3个模块组成，即策略选择网络、负载均衡网络和参数更新网络。

关键词：面向对象的存储系统；元数据；动态负载均衡；强化学习；Q_learning

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标题作者时间类型操作

Hot deformation behavior of a novel bimetal consisting of BTW1 and Q345R characterized by processing

Pengtao LIU, Lifeng MA, Weitao JIA, Tao WANG, Guanghui ZHAO

期刊论文

R158Q and G212S, novel pathogenic compound heterozygous variants in of Gitelman syndrome